Gen Rinpoche, in his commentary on the Meaning of said:

"The mantra Om Mani Pädme Hum is easy to say yet quite powerful,
because it contains the essence of the entire teaching. When you say the first syllable Om it is blessed to help you achieve perfection in the practice of generosity, Ma helps perfect the practice of pure ethics, and Ni helps achieve perfection in the practice of tolerance and patience. Päd, the fourth syllable, helps to achieve perfection of perseverance, Me helps achieve perfection in the practice of concentration, and the final sixth syllable Hum helps achieve perfection in the practice of wisdom.

So in this way recitation of the mantra helps achieve perfection in the six practices from generosity to wisdom. The path of these six perfections is the path walked by all the Buddhas of the three times. What could then be more meaningful than to say the mantra and accomplish the six perfections?"

The six syllables purify the six realms of existence in suffering.

For example, the syllable Om purifies the neurotic attachment to bliss and pride, which afflict the beings in the realm of the gods.

Om purifies bliss / pride gods
Ma purifies jealousy /lust for entertainment jealous gods
Ni purifies passion / desire human
Pe purifies stupidity / prejudice animal
Me purifies poverty / possessiveness hungry ghost
Hung purifies aggression / hatred hell