Yes- but this does not mean that relationships are predetermined. We may have certain karmic predispositions to feel close to or to have friction with certain people. But, this does not mean that our relationships with them must continue along the same lines. If we are kind to those who speak ill of us and try to communicate with them, the relationships will change - creating positive Karma that will bring happiness in the future.
We are not karmically bound to others- there are no special people who are the one and only one for us. Since we had many past lives, we have had contact with every being sometime before. Our relationship with any particular person also changes constantly. However, past karmic connections can influence our present relationships. For example, if someone has been our spiritual mentor in a past life, we may be drawn to that person in this lifetime, and when he or she teaches us the Dharma, it may have a very strong effect on us.